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KMID : 0381219910230030318
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Journal of RIMSK
1991 Volume.23 No. 3 p.318 ~ p.325
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The Efficacy of Biochemical Parameters of Serum and Ascitic Fluid in Differentiation of Cirrhotic and Malignant Ascites
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Abstract
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This study was performed to evaluate the diagnostic efficacy of the following biochemical parameters in differentiation of 48 patients with cirrhotic ascites and 44 patients with malignant ascites.
Concentration of total protein, albumin, cholesterol and LDH in ascitic fluid were measured and each of their serum to ascites concentration gradient and ratio were compared between two groups.
The cut-off value of total protein concentration in ascitic fluid {(Asc)protein) was 2.5 g/dl, serum-to-ascites gradient {(S-Asc)protein} 4.15 g/dl and ascites-to-serum ratio ( (Asc:S)protein) 0.6, respectively.
In albumin, 0.48 g/dl for ascitic fluid albumin ((Asc)albumin), 1.1 g/dl for gradient {(S-Asc) albumin} and 0. 19 for ratio {(Asc:S)albumin}.
In cholesterol, those were 22 mg/dl for {(Asc)cholesterol), 125 mg/dl for ((S-Asc)cholesterol) and 0. 17 for ((Asc : S)cholesterol).
Mean ascitic fluid LDH concentration was 37 IU/L.
Applying these cut-off values, the efficacy of each parameter was as follows: 1) {(S-Asc)protein) 73%, 2) ((S-Asc)protein} 70%, 3) ((Asc:S)protein} 63%, 4) {(Asc)albumin) 80%, 5) ((S-Asc) albumin) 76%,6) {(Asc:S)albumin) 70%,7) {(Asc)cholesterol} 84%,8) {(S-Asc)cholesterol} 75%, 9) ((Asc:S)albumin) 81%, 10) LDH 83%, respectively.
From these results, we can make a conclusion that ascitic fluid concentration of albumin and cholesterol, serum-to-ascites concentration ratio of albumin and cholesterol offer an excellent and cost-effective discrimination between cirrhotic and malignant ascites.
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KEYWORD
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